Ketocollasis is a multi-functional cosmetic material based on small-molecule metabolites derived from the body. It is a safe and biocompatible biomaterial that maximizes penetration into the skin through the derivatization of ketoglutaric acid, which is one of the main components found in all the organisms using the TCA circuit. It is involved in the biosynthesis of collagen, one of ECM’s main proteins, and used as an energy source and antidote in the human body. As an epigenetic biomaterial, it also has high utilization value in multi-functional cosmetic products.