A drug delivery system is a technology to minimize side effects by focusing on the target area and designing and optimizing a formulation to ensure efficient drug delivery. 3D nHA is a biopolymer that we developed. As an ultrafine hyaluronic acid nano-gel, it collects a drug with a porous structure of less than 10nm and uses no cross-linking agents to offer superb biocompatibility. This material can be applied to a variety of uses including dental filling materials, wound dressing agents, fillers, anti-adhesion agents, scaffolds, and cosmetics.