PROLIPHIL-F4 is a peptide fragment comprising collagen protein and peptide-fatty acid derivant to facilitate collagen biosynthesis by increasing the activity of prolidase, an enzyme that plays an important role in collagen synthesis. PROLIPHIL-F4 has a superb penetration action into cell and skin tissues, reaching the dermis effectively. It also facilitates collagen biosynthesis effectively, improving wrinkles and skin firmness. Its efficacy has been demonstrated in clinical tests.